Was [IPp] Headlines in today's paper Now basals
Hi Manuela
Ellie is 11 and has quite a low basal %, usually around 35-40%, but when it
dropped to 25% her control was not so good. We got it back up to 40% and
control is great again.
We also had 0.05 between 11am and 6pm. Now she has 0.15 11am - 6pm, and her
mid morning snack ratio is 20g to stop her going low before lunch. We
decided to slightly drop the insulin for lunch and tea . She has 12g to
1unit at breakfast, 15g at lunch and 18g at tea. To counteract the post
breakfast spike she boluses 2.5 units before breakfast and tops up
afterwards. Her rates are
12mn-5am 0.4
6- 10am 0.35
11-6pm 0.15
6-10pm 0.3
10pm -12mn 0.5units.
Liz
mum to Eleanor (aka Ellie) 11 (dx 11/ 2002) pumping novorapid with minmed
512 and 6mm Quicksets since 20/10/04
> Hi everybody,
> as Giulia, 8, 31kg, is quite destabilized, I started to check again,
> the boluses, the BR,.... and I realized that her basal rate is only
> 25 % of her total daily insulin (humalog).
> From 12am to 4am she has 0.35,
> 4am to 8am : 0.4
> 8am to 12pm: 0.05 it is very low indeed but if I give her more she
> arrives at lunch with a BG of less than 40; and the breakfast bolus
> (combined) has to be strong otherwise her 10amBG is higher than 250
> 12pm to 8pm 0.30
> 8pm to 12am: 0.40
>
> If her 10pm BG is normal she wakes up fine. So it seems that her
> basal rate is OK.
> Any suggestions or whatsoever? Thank you.
> Manuela
>
> Le 27-mars-06 ` 21:36, Manuela Tori a icrit :
>
> > Thank you Hilary for sending infos like that,
> > Manuela, mom of Giulia, 8, dx 08/98, cozmo
> > Le 27-mars-06 ` 17:58, Hilary Gilmore a icrit :
> >
> >
> >> Doctors seek diabetes breakthrough
> >>
> >>
> >>
> >>
> >>
> >>
> >>
> >> By Jennifer Bails <mailto:email @ redacted>
> >> TRIBUNE-REVIEW
> >> Monday, March 27, 2006
> >>
> >> Children's Hospital of Pittsburgh researchers are expected to receive
> >> federal clearance today to inject patients with their own genetically
> >> altered immune cells in what could be a major step toward curing
> >> type 1
> >> diabetes.
> >>
> >> "This is the first time that we can see the light at the end of the
> >> tunnel," said Dr. Massimo Trucco, Hillman professor of pediatric
> >> immunology at the Oakland hospital, who is leading the preliminary
> >> clinical trial approved by the U.S. Food and Drug Administration.
> >>
> >> Trucco, a native of Italy who has been hunting for a diabetes cure
> >> for
> >> more than 20 years, said his research team will be able to determine
> >> within six months if the vaccine is safe and then proceed with more
> >> extensive trials.
> >>
> >> Type 1 diabetes affects about 1.3 million Americans whose lives
> >> depend
> >> on daily insulin injections.
> >>
> >> Diabetes begins in the pancreas.
> >>
> >> In a healthy pancreas, cell clusters known as the Islets of
> >> Langerhans
> >> release the hormone insulin to help the body harvest energy from
> >> food by
> >> breaking down sugar. For reasons still not fully understood, the
> >> body's
> >> immune system sometimes goes haywire and destroys its own
> >> insulin-producing machinery.
> >>
> >> The result is type 1 diabetes, sometimes called juvenile diabetes
> >> because it usually appears during childhood. Type 2 diabetes, in
> >> which
> >> the body continues to produce insulin but no longer responds to
> >> it, is a
> >> different disease associated with older age and obesity.
> >>
> >> Type 1 diabetics must monitor their diets carefully and are at
> >> high risk
> >> of heart disease, blindness, nerve damage and kidney failure. They
> >> are
> >> likely to die sooner than people without the disease.
> >>
> >> Traditional vaccines, for infectious diseases such as polio and
> >> influenza, trick the body into producing protective antibodies and
> >> specialized immune cells.
> >>
> >> Instead of defending against foreign invaders, the Children's
> >> diabetes
> >> vaccine will stop the body from attacking itself.
> >>
> >> "In this case, we are trying to apply these vaccines to teach the
> >> immune
> >> system to behave itself," said diabetes researcher Dr. Michael
> >> Clare-Salzler of the University of Florida College of Medicine.
> >> Clare-Salzler is not involved in the Children's trial, but he is
> >> using
> >> similar techniques to develop his own version of a diabetes vaccine.
> >>
> >> To develop their vaccines, Trucco and Clare-Salzler are harnessing
> >> the
> >> power of scavenger-like immune cells called dendritic cells.
> >>
> >> In type 1 diabetics, the insulin-producing cells in the pancreas
> >> start
> >> to die off. Then, dendritic cells gobble up the remains using their
> >> long, spiky arms. The dendritic cells migrate to the pancreatic lymph
> >> nodes with the debris, triggering the production of T-cells, which
> >> return to the pancreas and destroy more insulin-producing cells.
> >>
> >> Three genes on the surface of the dendritic cells enable this vicious
> >> cycle leading to type 1 diabetes.
> >>
> >> In experiments involving mice destined to develop diabetes, Trucco
> >> and
> >> University of Pittsburgh School of Medicine immunologist Nick
> >> Giannoukakis have shown they can silence the harmful T-cells to
> >> significantly delay onset of the disease by blocking these genes.
> >>
> >> Up to 45 weeks after a single injection of genetically altered
> >> dendritic
> >> cells, 20 percent of the mice tested remained diabetes-free, the
> >> researchers reported in the Journal of Immunology in October 2004.
> >>
> >> The researchers hope to achieve similar results in people by testing
> >> 18-year-olds recently diagnosed with Type 1 diabetes.
> >>
> >> "These types of approaches have been very successful in mouse
> >> studies,
> >> but whether they can be translated to humans -- we still have a
> >> lot of
> >> work to do," Clare-Salzler said.
> >>
> >> Here's how the trial will work:
> >>
> >> * Blood drawn from seven patients will be pumped into a machine that
> >> separates white blood cells from other cells. From these white blood
> >> cells, the scientists will isolate the dendritic cells.
> >>
> >> * The dendritic cells will be treated with strands of genetic
> >> material
> >> designed to block the three key genes.
> >>
> >> * These genetically altered immune cells will be injected back
> >> into the
> >> patients. Every week for six weeks, each patient will receive three
> >> injections containing millions of their own modified cells.
> >>
> >> * The patients will be compared with seven patients injected with
> >> their
> >> own dendritic cells that haven't been genetically altered.
> >>
> >> If no adverse side effects occur, Trucco and Giannoukakis will be
> >> able
> >> to proceed with further testing to see if the vaccine helps to
> >> reverse
> >> the course of diabetes in similar patients. Studies show that
> >> insulin-producing cells can come back to life after T-cells attack
> >> them,
> >> but it is unclear how long this "honeymoon phase" lasts after
> >> diabetes
> >> strikes.
> >>
> >> The researchers also hope to test the vaccine in non-diabetic
> >> patients
> >> at high risk of developing the disease to see if onset can be
> >> prevented
> >> altogether, as in the mice.
> >>
> >> In theory, the simplest avenue to a cure would be to transplant
> >> healthy,
> >> insulin-producing islet cells into a diabetic. But these transplanted
> >> islets tend to fail, and that method requires patients to spend a
> >> lifetime taking toxic anti-rejection drugs.
> >>
> >> Because dendritic vaccines are designed to treat patients with
> >> their own
> >> cells, they avoid the need for immunosuppressant drugs, making this a
> >> promising, although still untested, approach, Clare-Salzler said.
> >>
> >> Trucco, whose study is being funded by $850,000 from the National
> >> Institutes of Health, also recently received $1.8 million from the
> >> Juvenile Diabetes Research Foundation to test another complementary
> >> vaccine that would stop the destructive T-cells from being
> >> unleashed in
> >> the first place. He also has applied for funding from the U.S.
> >> Department of Defense.
> >>
> >> This type of treatment could be used in tandem with the dendritic
> >> vaccine to provide a one-two punch against type 1 diabetes that
> >> Trucco
> >> said could be the cure he has been pursuing for almost two
> >> decades. But
> >> even if the first two phases go as planned, he cautioned that a
> >> vaccine
> >> is at least two or three years away.
> >>
> >> "If we can have only one patient feeling better, I will be happy,"
> >> Trucco said. "I want to see one kid who is going around with an ice
> >> cream cone and not feeling guilty."
> >>
> >>
> >>
> >> Hilary Gilmore
> >>
> >> (mom to Phoebe, dxd at the age of 8 in March, 2004, pumping Animas IR
> >> 1200 September, 2004)
> >> .
> >>
> > .
> .
.
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